Patrick Griffin

Dr. Patrick Griffin is a postdoctoral fellow in Jason Buenrostro’s lab at the Broad Institute of MIT and Harvard and the Harvard Department of Stem Cell and Regenerative Biology. His current research bridges endocrinology and genomics technology. He studies how chronic psychosocial stress remodels endocrine tissues using single-cell multiomics, and he develops new platforms for single-cell epigenomic profiling. A central theme across his work is understanding how stress and our environment shape how we age.

He completed his PhD with David Sinclair in the Department of Genetics at Harvard Medical School, where he invented TIME-seq, a high-throughput method for epigenetic age profiling (Griffin et al., Nature Aging 2024), and built the first multiomic aging clocks in mice (Vera*, Griffin* et al., J Gerontol A 2025), contributing to work showing that loss of epigenetic information drives mammalian aging (Yang, Hayano, Griffin et al., Cell 2023).